DEAR MAYO CLINIC: What causes primary sclerosing cholangitis? How long does it take for it to progress?ANSWER: Primary sclerosing cholangitis, or PSC, is a chronic inflammatory disease of the bile ducts that may lead to severe liver damage and liver failure. PSC also can be associated with an increased risk of cancers in the liver, gallbladder, bile ducts and colon. The length of time it takes for the disease to progress can vary significantly. Unfortunately, there's currently no effective medical therapy for PSC. Many people with end-stage liver disease due to PSC are considered for a liver transplant.Bile ducts are the structures through which bile flows from the liver to the intestines. Bile helps the body absorb nutrients and other elements from food, and helps maintain the nutritional balance within the body. With PSC, "cholangitis" refers to inflammation of the bile ducts. "Sclerosing" describes the hardening and scarring of the bile ducts resulting from chronic inflammation.The … [Read more...] about Mayo Clinic Q&A: Time it takes for primary sclerosing cholangitis to progress varies
Sclerosing cholangitis symptoms
Credit: iStock.com/hotka Understanding your stools—also known as poop—can help you understand exactly what is going on within your digestive system. You may be justifiably quite startled to see a different color than the common brown, such as an orange stool. What is the healthiest poop color? A healthy bowel movement is one in which your stool (poop) is well-formed, soft, easily passed, medium brown in color, and has an “S” or “C” shape. Any brown shade will often indicate a healthy stool with no digestive or diet problems. What about other stool colors? Red commonly indicates hemorrhoids; black could be bleeding in the gastrointestinal tract; green often means food is moving through the colon too quickly, possibly from diarrhea; and yellow, greasy, and foul-smelling stools can be due to excess fat in the stool, possibly from a malabsorption problem like celiac disease. However, while some colors suggest a potential health issue, an orange … [Read more...] about What Causes Orange Stool?
Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. Symptoms of mesenteric panniculitis can vary between individuals but often include inflammation and abdominal pain. In this article, we look at the causes and symptoms of mesenteric panniculitis, as well as how the symptoms are managed. Mesenteric panniculitis is a chronic disorder that affects fat cells in the mesentery. The mesentery is a fold of tissue in the abdomen that attaches the intestine to the abdominal wall to hold it in place. Mesenteric panniculitis causes persistent inflammation, which can damage or destroy fat cells in the mesentery. This can lead to scar tissue and other symptoms. There are three stages of mesenteric panniculitis. These are: Mesenteric lipodystrophy, which is when the fat cells start to be replaced by cells from the immune system. Mesenteric … [Read more...] about What is mesenteric panniculitis?