Back in 2004 I made the claim that the serotonin 2A receptor (5HT2AR) would be crucial for brain mechanisms of REM sleep and the peculiar phenomenology of dreams (McNamara, 2004). Why is this claim important? If we can identify a pharmacologic mechanism that reliably alters dream phenomenology, we can potentially develop pharmacologic treatments for those disorders. What is the evidence that 5HT2A signaling is particularly important for REM dream phenomenology? Well, there is a class of drugs that bind to the 5HT2A receptor pretty strongly. These are the so-called atypical anti-psychotics. Administration of these antipsychotic agents that antagonize the 5HT2A receptor improves cortical function, eliminates hallucinations and ameliorates schizophrenic symptomology. These clinical facts suggest that 5HT2A signaling mechanisms may actually produce the hallucinatory and bizarre cognitive states associated with psychosis. Given the fact that some dreams are like psychotic or … [Read more...] about 5HT2A Serotonin Receptor System in Dreaming
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Taking our goals in stride... Source: Yftaheco via Wikimedia Commons Many of our important projects and goals require extended effort – effort stretched out over long periods of time, from months, to years, or even decades. What keeps us going on these projects, pursuing our long-term goals, even when, in the short-term, the road ahead seems riddled with bumps and potholes, steep hills to climb, or unanticipated setbacks? Imagine you are embarking on an ambitious new creative project – say you want to launch your first solo artist exhibition of paintings or sculptures, or your first interactive video+sound installation, or to publish a substantial written work such as a novel, or an extended theoretical or historical analysis. Should you set highly specific and concrete attainable goals for each day, or for each week? But we have many aspirations and hopes – should you be able to tell yourself just why this project is the one you … [Read more...] about What Keeps Us Going Creatively When the Going Gets Tough?
Home Fashion Bollywood wardrobe Bollywood Wardrobe Aayushi Adhaulia By Aayushi Adhaulia | on December 16, 2019 The Kapoor sisters, Kareena and Karisma have been ruling the Bollywood industry with their gorgeous looks and impeccable fashion sense. Recently, the duo once again caught our attention with their ethereal designer outfits as they attended their cousin Armaan Jain's engagement ceremony with Anissa Alia Malhotra. While Karisma Kapoor was dressed to impress in a silk two-piece ensemble, Kareena Kapoor Khan, on the other hand, flaunted her desi avatar with a bright red ethnic suit. So, let us take a close look at their outfits and decode it. Karisma Kapoor In A Silk Two-Piece Ensemble Karisma Kapoor donned a half-sleeved V-shaped plunging neckline nude-hued long silk kurta, which was accentuated by elaborate embroidered patterns. Styled by Esha Amiin, she wore a classic white shirt with her kurta, that went well with her look. The actress teamed it with matching silk … [Read more...] about Kareena Kapoor Khan And Karisma Kapoor Give Wedding Fashion Goals With Their Ethereal Outfits
Home Fashion Bollywood wardrobe Bollywood Wardrobe Devika By Devika Tripathi | on September 5, 2018 MxS launch party previous week was a star-studded affair and was definitely the biggest party of the week gone by. MxS- a luxury prêt brand founded by Monisha Jaising and Shweta Bachchan is one of the hugest brands launched this year. From Bachchans to Khans to Kapoors, the party witnessed the A-listers of Bollywood. Western fashion ruled the day and we must say that none of the celebs disappointed us. So, let's find out who-wore-what at MxS launch party. Abhishek And Aishwarya The duo came in contrasting attires. While Abhishek opted for a simple look, Aishwarya suprised us in a quirky avatar. Abhishek sported an MxS 'Girl Power' hoodie and teamed it with denims and sports shoes. Ash, on the other hand, wore an Abu Jani and Sandeep Khosla's beaded silk embroidered exotica coat, which was enhanced by eye-catching prints. Karisma Kapoor Karisma Kapoor was the glamorous … [Read more...] about From Bachchans, Khans To Kapoors, The Celebs Who Wore Dazzling Outfits At The MxS Launch Party
Source: Carl Pickhardt Ph. D. At this celebration time of year, I like to commemorate a gift I received many years ago from an older client who referred to adolescence by a term that poetically captured for me the coming of age passage. “Climbing Fool’s Hill,” he called it, and the story I imagined to go with it went like this: “I’ll describe it to you the way my grandfather once explained it to me many years ago, when at the proud age of 10, I stopped by to tell him that I was fed up with my parents, didn’t need them anymore, and was running away from home. Well, he didn’t say anything at first. Just got out some bread and jam and soda and proceeded to feed me the way he always did. “It’s hard traveling on an empty stomach,” he said at last. “And it sounds like you’re ready to do some serious climbing.” “How’s that?” I asked. “Well, when I was your age it was … [Read more...] about The Story of Adolescence