Credit:iStock.com/belchonock Magnesium is an essential nutrient that is crucial for many of your body’s vital functions, including protein synthesis, proper muscle function, blood pressure and blood sugar control, energy production, and proper bone development. In fact, magnesium is actually responsible for over 300 of the body’s reactions! It is also essential for many of your body’s enzyme functions. Because of its important role in the body, it’s vital to recognize any magnesium deficiency symptom. Magnesium is found naturally in many foods that you may eat on a daily basis, such as almonds, cashews, peanuts, green leafy vegetables, soy milk, black beans, edamame, and avocados. A good rule of thumb to go by is that if a food is a significant source of dietary fiber, then it likely contains a good amount of magnesium too. Unfortunately, many people do not get the RDA of magnesium, and are thus at risk of magnesium deficiency symptoms. It’s … [Read more...] about Why Magnesium is Important? Deficiency Symptoms and Associated Diseases
Researchers have discovered a mechanism through which toxic protein clusters develop in the brain in Parkinson's disease. It may be treatable with drugs approved for another disease. In a paper published in the journal Neuron, the scientists describe how they discovered that increasing a fatty substance, or lipid, called glucosylceramide causes a buildup of toxic clusters of alpha-synuclein protein inside dopamine-producing brain cells. The team also revealed that treatment with an already approved glucosylceramide synthase inhibitor — a drug that reduces production of the lipid — reduced the toxic protein clusters, which are a hallmark of Parkinson's disease. "Some companies," says senior study author Joseph Mazzulli, an assistant professor of neurology at Northwestern University Feinberg School of Medicine in Chicago, IL, "have been using synthase inhibitors to reduce the synthesis of the lipid, and we used a similar compound on patient-derived neurons in our … [Read more...] about Could an existing drug halt Parkinson’s disease?
New research with implications for the treatment of Parkinson's disease suggests that when we want to move, all our brain needs is a quick burst of dopamine. The results, by scientists at the Champalimaud Center for the Unknown in Portugal as well as Columbia University in New York City, NY, question the idea that the brain needs a constant level of dopamine for normal movement. A report on the study, published in the journal Nature, describes how immediately before they initiated movements, the associated neurons, or nerve cells, showed peaks in dopamine activity. "Our most important result," says first study author Dr. Joaquim Alves da Silva, a psychiatrist and neuroscientist from the Champalimaud Center and the Nova University of Lisbon in Portugal, "is that we showed, for the first time, that the change in neural activity is necessary to promote movement." "And, also for the first time," he continues, "we showed that the dopamine peak that precedes movement initiation does not … [Read more...] about Parkinson’s disease: Boosting dopamine promotes movement
While the exact cause of Parkinson's disease is unknown, the development of the condition is influenced by many genetic and environmental factors. Doctors have identified how mutations in some genes can be passed down through generations and may lead to an increased risk of Parkinson's disease. Parkinson's disease is a condition that affects the brain, particularly the areas that control movement and balance. It can cause worsening neurological changes that often start with tremors and muscle rigidity. It also increases a person's risk of depression and dementia. In this article, learn about how genetics affect the development of Parkinson's disease, and when to talk to a doctor about family history and genetic testing. An estimated 15 percent of people with Parkinson's disease have a family history of the condition. Doctors have identified genes that are passed down from family members that seem to increase a person's likelihood of developing Parkinson's. They have also identified … [Read more...] about Is Parkinson’s disease passed on through genetics?
Early-onset Parkinson's occurs when a doctor diagnoses the disease in a person 21 to 50 years old, according to the American Parkinson Disease Association. While a Parkinson's diagnosis can be devastating at any time of life, being diagnosed with the disease at an early age can significantly impact a young person's quality of life and that of their family. Currently, there is no cure for the disease. Because doctors most often diagnose Parkinson's disease in people around 60 years old, it is likely that a much younger person with early-onset Parkinson's disease could remain undiagnosed or misdiagnosed for some time. Early-onset Parkinson's may also progress differently to the more traditional form of the disease. Being aware of symptoms and risk factors may help a person get the treatments they need as early as possible. According to the American Parkinson Disease Association, an estimated 10 to 20 percent of those with Parkinson's disease are diagnosed at an early age. This amounts to … [Read more...] about What is early-onset Parkinson’s disease?