First, there was the great hope of induced pluripotent stem cells (iPSCs), and then there was the inevitable letdown. When the announcement came, in 2006, that simple adult skin cells could be reprogrammed – reverted back to an embryonic stem cell state by the addition of just four genes – it seemed like an almost magical solution to the problems of using stem cells from embryos. But then some studies started to find that the reprogramming process was not perfect – iPSCs were similar, but not identical, to the cells from early embryos. More critically, only about 1% of the cells treated with the four-gene combination actually turn into iPSCs, and the process is painstakingly slow – around four weeks. That is just fine for a research lab, not so great for developing medical applications. Of course, labs everywhere have been working to improve the process. So today’s report of a Weizmann Institute finding that can raise that conversion rate to 100% is, for … [Read more...] about 100% Success in Gene Reprogramming
Drew Costley, SFGATE Published 9:28 am PDT, Sunday, March 17, 2019 A lab mouse. A lab mouse. Photo: Adam Gault/Getty Images Photo: Adam Gault/Getty Images Image 1 of / 29 Caption Close Image 1 of 29 A lab mouse. A lab mouse. Photo: Adam Gault/Getty Images UC Berkeley gene therapy helps blind mice gain sight, could be used to cure blindness 1 / 29 Back to Gallery A team of scientists at UC Berkeley used a breakthrough gene therapy to help blind mice gain sight, and some on the team think the same therapy could eventually be used to help cure blindness in humans. A month after the team injected a gene for a green-light receptor into the eyes of blind mice, they showed signs of … [Read more...] about UC Berkeley gene therapy helps blind mice gain sight, could be used to cure blindness
If there is one cause of cancer, it would be genetic damage to somatic cells. So all we have to do to cure cancer is prevent all genetic damage! That's not a very useful prescription, unfortunately; it's rather like saying that all we have to do to prevent accidental deaths is prohibit all potential causes of injury. The causes of genetic damage are ubiquitous. We're familiar with some. Smoking, for instance, irritates and damages the cells of the lung epithelium, and increases the rate of cancer incidence. UV radiation damages DNA, so prolonged exposure to the sun increases the rate of skin cancer. Chimney sweeps would get covered in the carcinogenic compounds present in soot, which would accumulate in folds of skin, and had phenomenal rates of scrotal cancer. So don't clamber around in chimneys, stay in the dark all the time, and never start smoking, and you won't get cancer, right? Wrong. You've eliminated some factors that increase the incidence of cancer, but not all. You might … [Read more...] about Cancer: bad genes or bad luck?
Founder and CEO of The ODIN, Josiah Zayner extracts Follistatin protein used in their frog gene therapy kit during a demonstration in Oakland, Calif., on Thursday, Jan. 1, 2019. The genetic engineering company creates kits and tools for individuals to make unique and usable organisms at home or in a lab. (Anda Chu/Bay Area News Group) Founder and CEO of The ODIN, Josiah Zayner holds a green tree frog in Oakland, Calif., on Thursday, Jan. 1, 2019. The genetic engineering company uses the frogs in their Frog Genetic Engineering Kit – Learn to Genetically Modify Animals that they sell. (Anda Chu/Bay Area News Group) Founder and CEO of The ODIN, Josiah Zayner holds a green tree frog in Oakland, Calif., on Thursday, Jan. 1, 2019. The genetic engineering company uses the frogs in their Frog Genetic Engineering Kit – Learn to Genetically Modify Animals that they sell. (Anda Chu/Bay Area News Group) Founder and CEO of The ODIN, Josiah Zayner extracts Follistatin … [Read more...] about New gene-editing kit puts the power of frog growth into citizen scientists’ hands
Wednesday, January 02, 2019 by: Russel Davis Tags: Alzheimer's disease, Brain, brain health, dementia, goodfood, goodhealth, Green tea, mental health, Mind, plantmedicine, tea (Natural News) Daily consumption of tea may help keep dementia at bay, new research says. Researcher at the National University of Singapore examined the tea intake of 957 adults older than 55 years old for more than 12 years. Study data show that regular tea consumption is associated with a 50 percent reduced risk of developing dementia. Data also reveals that people carrying the dementia gene may decrease the risk of beta-amyloid plaque formation by 86 percent. Beta-amyloid plaques is shown to trigger the onset of cognitive disorders in patients. Researchers note similar effects regardless of whether the tea was green or black. “The data from our study suggests that a simple and inexpensive lifestyle measure such as daily tea drinking can reduce a person’s risk of … [Read more...] about Daily green tea consumption found to slash dementia risk by up to 86%